Nancy-Ann DeParle, among the most prominent women in President Barack Obama's inner circle, is set to depart her White House post after his second-term inauguration.

DeParle, deputy White House chief of staff, will join the Brookings Institution later this month and also begin lecturing at Harvard Law School. News of DeParle's departure was announced Friday by Brookings Institution's president, Strobe Talbott.

Earlier this week, Labor Secretary Hilda Solis announced she would resign. EPA Administrator Lisa Jackson and Secretary of State Hillary Clinton also are on their way out.

DeParle, among the president's key point persons during the drafting of the health care bill in 2010, was thought to be under consideration to replace Jack Lew as President Obama's chief of staff. Obama nominated Lew earlier this week to be the next Treasury secretary.

The White House did not comment on DeParle's exit.